Structural analysis of cosmetics ingredients 0600-S2-ChK-ASSK
During the course. Students will learn the methods for solving the phase problem for small molecular compounds and proteins. The specificity and limitations of the protein crystallography methods will be presented. Students will learn all stages of the diffraction experiment, from the selection of good quality crystals, sample mounting, to collecting the diffraction data with the use of the modern software. Students will learn how to solve and refine the structures of the organic compounds. Students will learn the methods of the protein structure prediction, analysis of the active site, and to retrieve the structural data from the structural databases for small molecules (CSD) and proteins (PDB). Students will learn the molecular modeling methods for the protein-ligand systems.
Total student workload
Learning outcomes - knowledge
Learning outcomes - skills
Learning outcomes - social competencies
Teaching methods
Expository teaching methods
- problem-based lecture
Exploratory teaching methods
- project work
Type of course
Prerequisites
Course coordinators
Assessment criteria
• The computer laboratory will be graded based on the report from the project. Student has to get 50% possible points.
W01, W02, W03, W04, W05, U01, U03,U04, K01, K02, K03
• Written examination (assessed in %) (W01, W01, W02, W03, W04, W05)
Practical placement
N/A
Bibliography
1. T. Penkala, Zarys Krystalografii, PWN Warszawa, 1977,
2. Z. Bojarski, M. Gigla, K. Stróż, M. Surowiec, Krystalografia, PWN, 2014,
3. Z. Trzaska-Durski, H. Trzaska-Durska, Podstawy Krystalografii Strukturalnej i Rentgenowskiej, PWN, 1994,
4. International Tables For X-ray Crystallography.
5. J. Drenth, Principles of Protein X-Ray Crystallography, Springer-Verlag, 2010.
Additional information
Additional information (registration calendar, class conductors, localization and schedules of classes), might be available in the USOSweb system: