Elements of photochemistry in medicine 0600-S1-CM-PW7b-Va
Lecture:
The lecture contains information on the nature of electromagnetic radiation, the interaction of light with matter and its impact on living organisms. Basic concepts and laws of photochemistry, issues related to the absorption of radiation and excited states of molecules and the processes of quenching of excited states, fluorescence and phosphorescence, the Jabłoński diagram, quantum efficiencies, energy and electron transfer processes will be discussed. Examples of photochemical reactions and materials used in medicine (photopolymer implants, prostheses, eye lenses, composite dental fillings, photosensitive compounds in medical diagnostics) and pharmacy (photopolymer drug carriers with controlled release), as well as the use of UV radiation as a factor in photodynamic therapy will be presented. anti-cancer and as a sterilizing agent
Artificial sources of UV radiation, methods of testing photochemical reactions and actinometric methods will be discussed.
Lab:
Laboratory exercises are devoted to the detection of singlet oxygen produced in photochemical reactions, examining the influence of UV radiation on the decomposition of a selected dye in the presence and absence of catalysts, examining photochromic processes in organic compounds, examining photochemical transformations of pyrimidine and purine bases (as model compounds of proteins), examining photosensitization processes and photostabilization.
Total student workload
Learning outcomes - knowledge
Learning outcomes - skills
Learning outcomes - social competencies
Teaching methods
Expository teaching methods
Type of course
Prerequisites
Course coordinators
Term 2022/23Z: | Term 2020/21: | Term 2021/22Z: | Term 2023/24Z: |
Assessment criteria
Lecture: written exam – W1-W4.
Laboratory: credit based on completed laboratory exercises and studies - W1, W2, W4, U1, U3, U4, U5, K1-K3, continuous assessment of the student's work during classes - U3, U5, K1-K3.
Exam requirements:
1. Electromagnetic radiation, photochemical laws.
2. Processes of absorption, excitation and photosensitization of molecules.
3. Jabłoński's diagram.
4. Excimers and exciplexes.
5. Quantum efficiency.
6. Energy and electron transfer processes.
7. Photochemical reactions, photosensitive compounds.
8. Actinometry.
9. The influence of light on living organisms.
10. The use of UV radiation in medicine and pharmacy.
Bibliography
1. S. Paszyc, Fundamentals of photochemistry, PWN, Warsaw 1992.
2. J.A. Baltrop, J.D. Coyle, Photochemistry - basics, PWN, Warsaw 1987.
3. P. Suppan, Chemistry and light, PWN, Warsaw 1997.
4. Collective work, J. Pączkowski (ed.), Photochemistry of polymers, Nicolaus Copernicus University Publishing House, Toruń 2003.
5. Collective work, J. Najbar, A. Turek (eds.), Photochemistry and optical spectroscopy. Laboratory exercises, PWN, Warsaw 2009.
6. W. Schnabel, Polymers and Light. Fundamentals and Technical Applications, Wiley-VCH, Weinheim 2007.
List of additional literature:
1. Collective work, B. Marciniak (ed.), Methods of investigating the mechanisms of photochemical reactions, Wydawnictwo UAM, Poznań 1999.
2. G. Wenska, Environmental photochemistry, Wydawnictwo UAM, Poznań 1997.
3. Z. Stasicka, Photochemical processes in the environment, Wydawnictwo UJ, Kraków 2001.
4. J. Guillet, Polymer Photophysics and Photochemistry, Cambridge University Press, Cambridge 1987.
5. N.J.Turro, V. Ramamurthy, J.C. Scaiano, Modern molecular photochemistry of organic molecules, University Science Books, Sausalito 2010.
Additional information
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