Angiogenesis in Physiology and Pathology. Facts and Myths 1700-OG-EN-ANGPaP

The main task of the lectures is to familiarize students with the detailed mechanisms of blood vessels formation via vasculogenesis (de novo blood vessel generation from vascular progenitor cells) and angiogenesis (formation of new blood vessels via extension or remodeling from existing capillaries). Formation of new blood vessels occurs in many physiological states (during development of the embryo, cycling changes of the female reproductive tract), as well as in pathological processes (such as diabetic retinopathy and wound healing). Angiogenesis has been shown to be related to tumor formation, prognosis, and response to treatment in many tumor types. Intratumoral microvessels can be related to tumor behavior or hormone secretion in different endocrine tumors.
Lectures (each topic is organized on 4 academic hours):
1. Elements regulating angiogenesis;
2. The origin and function of circulating endothelial progenitor cells;
3. The role of angiogenesis in physiological processes especially during embryo development;
4. Vasculo- and angiogenesis in tumor growth and invasion;
5. Vasculo- and angiogenesis in cardiometabolic diseases.

Całkowity nakład pracy studenta

Contact hours with teacher: - participation in lectures: 20 hrs, - consultations with an academic teacher: 4 hrs. - completion of the test: 1 hrs. The workload related to the activities requiring the direct participation of academic teachers is 25 hrs, which corresponds to 1.0 ECTS points. Self-study hours: - preparation for lectures: 3 hrs - reading literature: 10 hrs - preparation for test: 12 hrs The total workload related to the self-study hours is 25 hours, which corresponds to 1.0 ECTS point. Altogether: 50 hrs (2.0 ECTS)

Efekty uczenia się - wiedza

Student: W1: has basic knowledge of disturbances in organs and systems in the course of any type of cancer. A.W3. (laboratory medicine) W2: possesses knowledge related to significance of laboratory diagnostic tests in the physiology and pathology as well as in prognosis and monitoring of therapy. D.W03. (laboratory medicine) W3: is familiar with methods of evaluation of angiogenesis in physiological and pathological conditions. E.W05. (laboratory medicine) W4: is acquainted with new developments in vascular medicine. E.W32. (laboratory medicine)

Efekty uczenia się - umiejętności

Student: U1: is able to describe the pathophysiological processes in the course of neoplastic diseases. A.U12. (laboratory medicine) U2: can explain differences in the structure and functioning of the organism at different stages of individual development. A.U03.(laboratory medicine) U3: is capable of indicating the relationship between morphological abnormalities and the functions of tissues, organs and systems, clinical symptoms and diagnostic strategy. E.U01 (laboratory medicine)

Efekty uczenia się - kompetencje społeczne

Student: K1: understands the need for continually improve professional skills. C.U11. (laboratory medicine)

Metody dydaktyczne

Lectures: - informative lecture; - problem lecture; - conversation lecture; - didactic discussion.

Wymagania wstępne

To realize the described subject it is necessary to know elements of anatomy, physiology and biochemistry.

Koordynatorzy przedmiotu

Barbara Ciastek

Kryteria oceniania

Participation in all lectures is a condition of admission to the written test.
Written credit (W1, W2, W3, W4, U1, U2, U3, K1): 30 test questions based solely on the content of the lectures.

The points obtained are converted into marks according to the following scale:
* fail - 0-55%
* satisfactory - 56-67%
* satisfactory plus - 68-75%
* good - 76-83%
* good plus - 84-91%
* very good - 92-100%

Praktyki zawodowe

Nie dotyczy.

Literatura

Primary literature:
1. Teleanu RI, Chircov C, Grumezescu AM, Teleanu DM. Tumor angiogenesis and anti-angiogenic strategies for cancer treatment. J Clin Med. 2019;9(1):84.
2. Breier G. Angiogenesis in embryonic development--a review. Placenta. 2000;21 Suppl A:S11-5.
3. Martin A, Komada MR, Sane DC. Abnormal angiogenesis in diabetes mellitus. Med Res Rev. 2003;23(2):117-45.
4. Urbich C, Dimmeler S. Endothelial progenitor cells: characterization and role in vascular biology. Circ Res. 2004;95(4):343-53. Supplementary literature:
1. Edwards N, Langford-Smith AWW, Wilkinson FL, Alexander MY. Endothelial progenitor cells: New targets for therapeutics for inflammatory conditions with high cardiovascular risk. Front Med (Lausanne). 2018;5:200.
2. Zarychta E, Rhone P, Bielawski K, Michalska M, Rość D, Ruszkowska-Ciastek B. Anti-angiogenic efficacy in invasive breast carcinoma patients depends on clinicopathological determinants. Adv Med Sci. 2019;64(2):216-223.
3. Rhone P, Bielawski K, Ziołkowska K, Rość D, Ruszkowska-Ciastek B. Low pre-treatment count of circulating endothelial progenitors as a prognostic biomarker of the high risk of breast cancer recurrence. J Clin Med. 2019;8(11):1984.

Uwagi

W cyklu 2022/23Z:

None

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