(in Polish) Szczepienia i nanotechnologia - współczesne narzędzia do walki z chorobami 7404-SD-BIOL-SZN

The lecture topics include general issues related to the basic concepts used in modern epidemiology and vaccinology. Information is presented on the history and development of vaccinology with particular emphasis on discoveries that have contributed significantly to improving human health. In addition, the basics of the functioning of the immune system (characteristics and types of immunity, functions of immune system cells) and the mechanism of acquiring immunity through protective vaccinations are discussed. The content of the lectures includes the characteristics, composition, types and production process of currently used vaccines, taking into account their advantages and disadvantages. The objectives, indications and contraindications for vaccination are discussed. The lecture also covers new directions in the development of vaccine research, such as DNA vaccines, vector vaccines or anti-cancer vaccines.
The second part of the lectures covers issues related to nanotechnology and its application in medicine and medical diagnostics. Information is presented on the history of nanotechnology development, its wide use in various areas of human activity, and basic concepts related to this field of science are defined, such as nanomedicine or nanotoxicology. During the lectures, the advantages and disadvantages of various types of nanoparticles (liposomes, micelles, nanoemulsions, quantum dots, dendrimers, albumin or metal nanoparticles) are discussed in relation to the safety of their potential use in medicine. The subject of the lecture is also the use of nanostructures in controlled and directed transport of drugs, e.g. anticancer drugs, in early cancer diagnostics or in the production of prostheses and implants. Information is also presented on research on the effect of nanoparticles on the properties of immune cells, such as the production of endogenous pyrogens, the induction of phagocytosis or the production of free radicals.

Total student workload

Hours conducted with teachers (30 hours): - Participation in lectures - 30 Time dedicated to individual student work (45 hours): - preparation for the exam and attendance at the exam - 45

Learning outcomes - knowledge

W1: Defines the concepts of: acquired and innate immunity, humoral and cellular immune response, herd immunity, vaccine, adjuvant, serum, epidemic, pandemic, antigen, antibody, vaccination schedule, vaccinology - P8S_WG; P8S_WK W2: Describes discoveries contributing to the development of vaccines, components of protective vaccines, types of protective vaccines, methods of vaccine administration, stages of antigen presentation, mechanisms controlling defensive reactions - P8S_WG; P8S_WK W3: Describes the phenomenon of herd immunity, mechanisms of inflammation, mechanisms controlling defensive reactions, mechanisms of antigen-antibody interactions - P8S_WG; P8S_WK W4: Explains the relationship between conducting protective vaccinations and eliminating certain diseases in the population - P8S_WG; P8S_WK W5: Defines the terms: nanotechnology, nanoparticles, nanomedicine, nanotoxicology - P8S_WG; P8S_WK W6: Describes the effect of nanoparticles on the functioning of the body - P8S_WG; P8S_WK W7: Indicate the potential use of nanostructures in medicine and medical diagnostics - P8S_WG; P8S_WK W8: Indicates the benefits and risks of using nanotechnology in relation to humans and the environment - P8S_WG; P8S_WK

Learning outcomes - skills

U1: Discusses the latest achievements in biology and chemistry used in vaccine production and explains the ethical and social consequences of using population vaccinations – P8S_UW U2: Independently searches for information on the safety of vaccines in Polish and English specialist and popular science literature and the Internet and is able to assess the reliability of the information obtained – P8S_UW; P8S_UK; P8S_UO U3: Determines directions for further education in terms of the use of biology and chemistry in the development of new types of vaccines – P8S_UU; P8S_UO U4: Uses knowledge of nanotechnology for qualitative and quantitative analysis of biological material - P8S_UW U5: Assesses threats to human health and life caused by the lack of appropriate procedures guaranteeing the safety of using nanoparticles in medicine and diagnostics - P8S_UW U6: Assesses the impact of nanomaterial on the basic functions of immune cells and on the functioning of organs and tissues in the body - P8S_UW

Learning outcomes - social competencies

K1: Understands the need for further education in the field of using the achievements of biology and chemistry in the production of new generation vaccines – P8S_KR K2: Critically evaluates and promotes information from various sources regarding the production of safe vaccines – P8S_KK K3: Understands the need for continuous deepening of knowledge about nanotechnology and its impact on the development of society - P8S_KR; P8S_KK K4: Rationally and critically approaches information obtained from scientific literature and the media regarding the potential use of nanoparticles in medicine - P8S_KK K5: Is aware of the risks associated with the use of nanotechnology achievements - P8S_KR; P8S_KK

Teaching methods

Informative lecture (conventional) using multimedia presentations.

Expository teaching methods

- informative (conventional) lecture

Type of course

compulsory course

Prerequisites

Basic knowledge of human anatomy, physiology and immunology.

Course coordinators

Tomasz Jędrzejewski

Assessment criteria

Written exam – P8S_WG; P8S_WK; P8S_UW; P8S_UU; P8S_UO; P8S_KR; P8S_KK

Exam in the form of a single-choice test, required threshold for a satisfactory grade - 55-60%, 61-70% - satisfactory plus, 71-80% - good, 81-90% - good plus, 91-100% - very good

Bibliography

1. Regis E., Nanotechnologia : narodziny nowej nauki, czyli świat cząsteczka po cząsteczce, Warszawa: Prószyński i S-ka,2001.
2. Gonsalves K.E., Halberstadt C.R., Laurencin C.T., Nair L.S., Biomedical Nanostructures, New York: John Wiley & Sons, 2008.
3. Nanotechnologia : chemia i medycyna - Kamila Żelechowska. Wydawnictwo Politechniki Gdańskiej 2016.; Wyd. 2.
4. Nanotechnologia w medycynie i kosmetologii : podręcznik akademicki : praca zbiorowa / pod red. Andrzeja Zielińskiego. Redakcja; Wydawnictwo Politechniki Gdańskiej Wydawca 2018.; Wydanie I.
5. Immunologia - Jakub Gołąb, Marek Jakóbisiak, Witold Lasek, Tomasz Stokłosa. Wydawnictwo Naukowe PWN, 2017.
6. Bernatowska E., Grzesiowski P. Szczepienia ochronne obowiązkowe i zalecane - od A do Z. PZWL, 2013.
7. Mrożek-Budzyn D. Wakcynologia praktyczna. Alfa medica Press, 2013.

Additional information

Additional information (registration calendar, class conductors, localization and schedules of classes), might be available in the USOSweb system:

Description of 7404-SD-BIOL-SZN in USOSweb