Plant and animal cell receptors 7404-SD-BIOL-RKRZ

The topics of the lectures concern the characteristics of receptors functioning in plant and animal cells, with particular emphasis on similarities and differences and the evolution of receptor systems. The aim of the lecture is also to indicate that animal and plant cells exhibit different classification of receptors.The lecture is addressed to doctoral students of the AST school of and shows the diversity of chemical and physical signal perception systems in plant and animal organisms. The lecture will also discuss methods (genetic, biochemical, physicochemical, bioinformatics) for studying cell receptors.
The lecture topics include:

1. Chemical nature of signaling molecules in plants and animals.

Classification of receptors in plant and animal cells. Intracellular location of receptors and chemical nature of the received signal. Basic definitions: agonist, inverse agonist, antagonist, dissociation constant Kd of the ligand-receptor complex, methods of determining Kd
2. Structure of the cell membrane. Membrane microdomains involved in signal perception (lipid rafts, caveolae)
3. Metabotropic receptors of animal cells - structure, identification and characteristics. Rhodopsin - a model prototype of metabotropic receptors.
4. Adrenergic receptors - structure, mechanism of ligand binding and signal transduction. Pharmacology and regulation of adrenergic receptors. Designing drugs for RA.
5. Other animal metabotropic receptors with important pharmacological functions.
6. Plant metabotropic receptors - do they exist at all? GTG protein - a winding road to the discovery of abscisic acid (ABA) receptors
7. Catalytic receptors of animal cells - tyrosine kinases - insulin and epidermal growth factor receptor
8. Catalytic receptors of plant cells, part 1 - two-component system, receptor histidine kinases of ethylene and cytokines
9. Catalytic receptors of plant cells part 2 - serine-threonine receptor kinases of brassinosteroids and signal peptides
10. Are there ionotropic receptors in plants? Glutamic acid receptors
11. Animal ionotropic receptors - GABA receptor, nicotinic acetylcholine receptor
12. Animal intracellular receptors - steroid, retinoid, thyroid and fatty acid receptors
13. Intracellular plant receptors - receptors - ubiquityl ligases in the perception of auxins, jasmonates and gibberellins. Is there a membrane auxin receptor?
14. Other plant cell receptors: photoreceptors (phytochrome, cryptochrome), certain and enigmatic salicylic acid receptors.

2. Structure of the cell membrane. Membrane microdomains involved in signal perception (lipid rafts, caveolae)

3. Metabotropic receptors of animal cells - structure, identification and characterization. Rhodopsin - model prototype of metabotropic receptors.

4. Adrenergic receptors - structure, mechanism of ligand binding and signal transduction. Pharmacology and regulation of adrenergic receptors. Design of drugs acting on RA.

5. Other metabotropic receptors of animals with important pharmacological functions.

6. Metabotropic receptors of plants - do they exist at all? GTG protein - the winding road to the discovery of abscisic acid (ABA) receptors
7. Catalytic receptors of animal cells - tyrosine kinases - insulin and epidermal growth factor receptor
8. Catalytic receptors of plant cells part 1 - two-component system, receptor histidine kinases of ethylene and cytokines
9. Catalytic receptors of plant cells part 2 - serine-threonine receptor kinases of brassinosteroids and signaling peptides
10. Do ionotropic receptors exist in plants? Glutamic acid receptors
11. Ionotropic animal receptors - GABA receptor, nicotinic acetylcholine receptor
12. Intracellular animal receptors - steroid, retinoid, thyroid and fatty acid receptors
13. Intracellular plant receptors - ubiquitin ligase receptors in the perception of auxins, jasmonates and gibberellins. Is there a membrane auxin receptor?

14. Other plant cell receptors: photoreceptors (phytochrome, cryptochrome), certain and doubtful salicylic acid receptors.