Antioxidants - advances in food, cosmetic and medicinal chemistry of the 21st century
7404-AUTL
Program content of the lecture:
• Types and sources of free oxygen radicals and free radicals with an unpaired electron and reactive oxygen species.
• Mechanisms of free radicals for-mation and their influence on or-ganisms - positive and negative aspects.
• Application of active radicals and reactive oxygen species in the fo-od, cosmetics and medicine indu-stries.
• Effects of free radicals on cell structures: lipid peroxidation, pro-tein oxidation, modification of nucleic acids.
• Reasons and consequences of oxidative stress.
• Defence mechanisms against ac-tive radicals and reactive oxygen species.
• Antioxidant kinds: enzymes, gluta-thione, antioxidant proteins and peptides, and hydrophobic and hydrophilic antioxidants.
• Chemical structures of the most important plant and animal an-tioxidants and their influence on antioxidant properties.
• Problems and models for testing the bioavailability of antioxidants.
• Biomarkers - modern characteri-stics of antioxidant activity and oxidative stress status.
• Antioxidants and nutrigenomics.
• Analytical methods for determina-tion of individual antioxidants and antioxidant capacity (sample pre-paration, chromatographic tech-niques, spectroscopic and electro-chemical methods).
Total student workload
Hours with teacher:
- lectures - 30 h
Individual work:
-for exercises 5h
- for exams- 30h
All together 65h
Learning outcomes - knowledge
PhD Student:
W1. Knows the origin of active radicals, reactive oxygen and nitrogen species and free radical reactions.
W2. Explains the concepts and phenomena related to active radicals' role (positive and destructive) in food, cosmetology, and medicine.
W3. Knows the systems of protection and repair of organisms against oxidative stress.
W4. Knows the types, chemical structure, role and mechanisms of antioxidants' action.
W5. Knows the models for the research on the bioavailability of antioxidants and the biomarkers for the assessment of their protective effect.
W6. Knows the interactions between antioxidants and genes and their influence on disease risk.
W7. Knows the methods for the determination of antioxidants and antioxidant capacity.
Learning outcomes - skills
PhD Student:
U1. Can use professional terminology related to active radicals, free radical processes, oxidative stress, antioxidants, methods for the determination of antioxidant properties.
U2. Can describe the sources of generation of active radicals, mechanisms of their formation and action effects (physiological and pathophysiological).
U3. Characterizes the system of protection and repair of organisms against oxidative stress.
U4. Understands the antioxidants effects, mainly their chemical structures, on the processes in the human body and the food and cosmetic products.
U5. Can choose an appropriate method to assess the bioavailability of antioxidants, their protective action and antioxidant capacity.
Learning outcomes - social competencies
PhD Student:
K1. Is focused on acquiring new knowledge, skills and experience regarding active radicals, free radical processes, oxidation reactions, and the role of antioxidants.
K2. Knows the limitations of own knowledge and skills as well as understands the need for further education.
K3. Understands the need to disseminate knowledge about the influence and determination of free radicals and antioxidants in food, cosmetic and medicine products in an accessible way.
K4. Can precisely formulate questions to deepen own knowledge and better understand or complete missing elements of reasoning.
Teaching methods
Lecture with Power Point presentations.
Prerequisites
Basic knowledge of general chemistry, physical chemistry, organic chemistry, analytical chemistry, and biochemistry.
Course coordinators
Assessment criteria
Lecture W1-W7; U1-U5.
exam written test, open questions
Criteria:
50-60% – 3;
61-65% – 3+;
66-76% – 4
76-80% – 4+
81-100% – 5.
Additional information
Additional information (registration calendar, class conductors,
localization and schedules of classes), might be available in the USOSweb system: