Microorganisms application in pharmaceutical biotechnology
2600-S1-CM-WMBF
The aim of the lecture is to familiarize listeners with advanced and current knowledge of microbiology and pharmaceutical biotechnology. The characteristics of microorganisms capable of synthesizing medicinal substances, the mechanisms of action of biologically active compounds on eukaryotic cells and the mechanisms of resistance of pathogenic bacteria to antibiotics will be presented.
The lecture covers the following topics:
Key achievements in pharmaceutical biotechnology,
Microorganisms as a biological source of medicinal substances,
Obtaining strains capable of producing medicinal substances,
Biosynthetic products used in therapy,
Industrial production of selected biologically active compounds,
Conducting the biosynthesis process - selected examples.
Practical classes include:
Conducting the process of biosynthesis of antimicrobial compounds using actinomycetes and determining the activity of the metabolites produced by them in the post-culture fluid against selected bacteria and fungi; Antibiograms
Biosynthesis of B vitamins by bacteria and fungi.
Total student workload
Hours carried out with the participation of teachers (30 hours):
- participation in lectures – 10 h
- participation in exercises - 15 h
- consultations - 5 h
Time devoted to individual student work (20 hours):
- student's own work - 20 h
A total of 50 hours
Learning outcomes - knowledge
Has advanced and current knowledge of microbiology, biochemistry and immunology K_W01
Has knowledge of qualitative and quantitative methods used in microbiology K_W04
Demonstrates knowledge of current problems in the field of microbiology
knows basic methods of synthesis, isolation and analysis of chemical compounds, including biologically active ones K_W05
knows the relationships between the structure and activity of chemical compounds, including biologically active compounds K_W06
Learning outcomes - skills
K_U03
is able to use basic knowledge of biological sciences in biomedical research, describes the basic phenomena occurring in the cells of microorganisms
K_U04
is able to plan an experiment and use equipment to carry out a specific research task
K_U05
is able to develop experimental results
K_U06
is able to synthesize and analyze biologically active compounds
K_U07
can determine the functions of biologically active compounds produced by microorganisms for other human health.
Learning outcomes - social competencies
K_K01
understands the need for continuous improvement and improvement of professional competences
K_K02
is able to organize work and strives to complete assigned tasks
K_K03
is able to appropriately determine priorities in order to plan and implement a specific task
K_K05
knows and follows the rules and standards, cares for health and the natural environment
K_K06
understands the ethical and social aspects of the practical use of acquired knowledge and skills
Course coordinators
Teaching methods
conventional lecture.
practical classes - work in teams of 2-4 people according to prepared instructions and instructions of the teacher.
Type of course
compulsory course
Prerequisites
knowledge of the basics of microbiology, genetics, biotechnology
Assessment criteria
Lecture - test for grade.
Exercises - presence and involvement in classes, analysis of the results of experiments, written final test
passing grade (colloquium)
Practical placement
Bibliography
Z. Libudzisz i K. Kowal. Mikrobiologia techniczna. Politechnika Łódzka, 2012
M.K. Błaszczyk. Mikrobiologia Środowisk. PWN. 2010
Elimer E. Mikrobiologia techniczna
Additional information
Additional information (registration calendar, class conductors,
localization and schedules of classes), might be available in the USOSweb system: