Microorganisms application in pharmaceutical biotechnology 2600-S1-CM-WMBF

The aim of the lecture is to familiarize listeners with advanced and current knowledge of microbiology and pharmaceutical biotechnology. The characteristics of microorganisms capable of synthesizing medicinal substances, the mechanisms of action of biologically active compounds on eukaryotic cells and the mechanisms of resistance of pathogenic bacteria to antibiotics will be presented.
The lecture covers the following topics:
Key achievements in pharmaceutical biotechnology,
Microorganisms as a biological source of medicinal substances,
Obtaining strains capable of producing medicinal substances,
Biosynthetic products used in therapy,
Industrial production of selected biologically active compounds,
Conducting the biosynthesis process - selected examples.

Practical classes include:
Conducting the process of biosynthesis of antimicrobial compounds using actinomycetes and determining the activity of the metabolites produced by them in the post-culture fluid against selected bacteria and fungi; Antibiograms
Biosynthesis of B vitamins by bacteria and fungi.

Total student workload

Hours carried out with the participation of teachers (30 hours): - participation in lectures – 10 h - participation in exercises - 15 h - consultations - 5 h Time devoted to individual student work (20 hours): - student's own work - 20 h A total of 50 hours

Learning outcomes - knowledge

Has advanced and current knowledge of microbiology, biochemistry and immunology K_W01 Has knowledge of qualitative and quantitative methods used in microbiology K_W04 Demonstrates knowledge of current problems in the field of microbiology knows basic methods of synthesis, isolation and analysis of chemical compounds, including biologically active ones K_W05 knows the relationships between the structure and activity of chemical compounds, including biologically active compounds K_W06

Learning outcomes - skills

K_U03 is able to use basic knowledge of biological sciences in biomedical research, describes the basic phenomena occurring in the cells of microorganisms K_U04 is able to plan an experiment and use equipment to carry out a specific research task K_U05 is able to develop experimental results K_U06 is able to synthesize and analyze biologically active compounds K_U07 can determine the functions of biologically active compounds produced by microorganisms for other human health.

Learning outcomes - social competencies

K_K01 understands the need for continuous improvement and improvement of professional competences K_K02 is able to organize work and strives to complete assigned tasks K_K03 is able to appropriately determine priorities in order to plan and implement a specific task K_K05 knows and follows the rules and standards, cares for health and the natural environment K_K06 understands the ethical and social aspects of the practical use of acquired knowledge and skills

Course coordinators

Term 2024/25L:

Term 2023/24L:

Term 2025/26L:

Term 2022/23L:

Teaching methods

conventional lecture. practical classes - work in teams of 2-4 people according to prepared instructions and instructions of the teacher.

Type of course

compulsory course

Prerequisites

knowledge of the basics of microbiology, genetics, biotechnology

Assessment criteria

Lecture - test for grade.

Exercises - presence and involvement in classes, analysis of the results of experiments, written final test
passing grade (colloquium)

Practical placement

n/a

Bibliography

Z. Libudzisz i K. Kowal. Mikrobiologia techniczna. Politechnika Łódzka, 2012
M.K. Błaszczyk. Mikrobiologia Środowisk. PWN. 2010
Elimer E. Mikrobiologia techniczna

Additional information

Additional information (registration calendar, class conductors, localization and schedules of classes), might be available in the USOSweb system:

Description of 2600-S1-CM-WMBF in USOSweb