Genetics 2600-S1-CM-GEN

LECTURE: Branches of genetics. Founders of genetics. Definition of a gene. Levels of regulation of gene activity. Initiation and termination of transcription in prokaryotes. Operons and methods of their regulation. Regulons. Complexity of regulation of gene activity in eukaryotes. Mitochondrial genome. Mendel's laws, apparent and real deviations from Mendelian relations. Types of gene cooperation. Inheritance of quantitative traits. Heritability. Allelicity tests. Recombination and gene mapping. Mutations and their effects, including cancer. Genetic determination of sex. Non-Mendelian inheritance: extrachromosomal inheritance, maternal effect, epigenetic changes. Population genetics - Hardy-Weinberg law, factors disturbing population equilibrium. Human genetics with the basics of molecular diagnostics.

EXERCISES: Model organisms, basic genetic concepts. Transformation of bacteria by heat shock. Mendel's laws. Gene cooperation. Inheritance of sex-linked traits in humans. Gene mapping by linkage analysis. Human genetics - identification of human sex by PCR. Genetic determinants of human diseases - counseling and prevention.

Total student workload

1. Contact hours with an academic teacher: - participation in lectures - 10 hrs. - participation in laboratory work - 20 hrs. - consultations - 20 hrs. 2. Student's own work: - preparation for exercises/laboratories - 15 hrs. - preparation for the final test - 10 hrs.

Learning outcomes - knowledge

1. K_W11 - the student knows the basic concepts of organism and population genetics 2. K_W09 - the student discusses the laws of inheritance (Mendelian and non-Mendelian inheritance) 3. K_W10 - the student understands the dependence of phenotype on genotype and the influence of the environment on genotype 4. K_W10 - the student lists the factors disturbing the balance of the population 5. K_W10 - the student knows the basic methods enabling the analysis of genetic material 6. K_W08, K_W10 - the student explains how the method of recording genetic information enables the stability and variability of the genome

Learning outcomes - skills

1. K_U06, K_U08, K_U12 - the student interprets the results of observations of trait transmission and is able to determine the genotype based on experimental data 2. K_U12 - the student analyzes the data contained in pedigrees, is able to determine the method of inheritance of a trait 3. K_U12 - the student is able to determine the probability of a given trait occurring in subsequent generations and in the population based on experimental data 4. K_U08, K_U12 - the student determines gene linkage based on the data and calculates the distances between genes

Learning outcomes - social competencies

1. K_K01 - the student understands the need for continuous deepening of knowledge 2. K_K02 - rationally and critically approaches information obtained from the Internet and other sources of mass media, as well as common beliefs regarding information in the field of genetics 3. K_K03 - Expresses his/her own opinion regarding knowledge in the field of genetics supported by scientific foundations, respects the opinions of other people participating in the classes 4. K_K09 - the student is responsible for the entrusted equipment and the correct implementation of the task

Teaching methods

Lecture with multimedia presentation. Exercises - multimedia presentation, discussion, demonstration, solving genetic tasks based on the data provided.

Expository teaching methods

- informative (conventional) lecture

Exploratory teaching methods

- laboratory

Online teaching methods

- cooperation-based methods
- methods developing reflexive thinking

Type of course

compulsory course

Prerequisites

High school level knowledge of cell biology and genetics.

Course coordinators

Grażyna Dąbrowska

Assessment criteria

Assessment of auditorium exercises in the scope of knowledge and skills: continuous assessment (current preparation of students for classes and their activity). In the scope of social competences: the student's activity during classes and his/her commitment and teamwork are assessed. Assessment on a scale of 2-5.

Lecture - final written exam
Assessment criteria - required threshold for a satisfactory grade - 55-60%, satisfactory plus - 61-70%, good - 71-80%, good plus 81-90%, very good - 91-100%
Exercises - final written assessment and average of the grades obtained in classes.

Bibliography

1. Sadakierska-Chudy A., Dąbrowska G, Goc A. General genetics. Exercise script for biology students. ed., 1st, UMK Publishing House, 2004
2. Sadakierska-Chudy A. (ed.) General genetics. Exercise instructions for biology students. ed., 1st, UMK Publishing House, 2004
3. Piątkowska B., Goc A., Dąbrowska G. Collection of tasks and questions in genetics, ed., 1st, UMK Publishing House, 1998
4. Fletcher H.L., Hickey G.I., Winter P.C. Genetics. Short lectures. ed., 3rd revised, PWN, 2011
5. Bal J. (ed.) Molecular biology in medicine. Elements of clinical genetics. ed., 2nd revised, PWN 2007

Additional information

Additional information (registration calendar, class conductors, localization and schedules of classes), might be available in the USOSweb system:

Description of 2600-S1-CM-GEN in USOSweb