(in Polish) Cellular communication and signal transduction 2600-BK-CCBIOL-1-S2

Cell signalling: definition, basic principles and evolutionary strategies. Classification of cell signals. Models of cell signalling pathways.
The influence of the cellular environment in single- and multicellular organisms: the meaning/ significance of cell adhesion and intercellular connections.
Biological membranes as a place for the transfer and integration of information and for execution cell responses. Transport through membranes.
Membrane and intracellular receptors. Types, structure and functions of receptors, and regulation of their activity.
Principles of intercellular signal transmission: cascades of signaling molecules; the role of protein domains and switch proteins;
The interaction and cooperation of the signalling pathway.
Cell signaling molecules: 1) (Phyto)hormones, neurotransmitters, growth factors, cytokines; 2) Membrane and intracellular receptors; 3) G proteins, cyclases and cyclic nucleotides; 4) Protein kinases and protein phosphatases; 5) lipid phosphates and the products of their metabolism; 6) Calcium signalling; 7) Reactive oxygen and nitrogen species.
Physiological consequences of cell signalling: growth, differentiation, ageing and cell death.
The effects of cell signaling pathology.

Total student workload

5 ECTS=125h 45 hours of direct contact with the teacher (1.8 ECTS) 80 hours of independent student work (3.2 ECTS): - writing projects and reports – 20 h - repetition and extended study – 20 h - preparation to pass the lab test – 20 h - preparation to pass the final test – 20 h

Learning outcomes - knowledge

W1: Student has basic knowledge of intracellular and extracellular signalisation K_W01 W2: Student classifies and characterizes receptors K_W02 W3: Student explains cell signal transduction mechanisms K_W04 W4: Student is familiar with extracellular communication systems K_W05

Learning outcomes - skills

U1: Based on the example, student analyzes signal propagation from receptor to effector K_U01, U2: Student uses the knowledge on structure and properties of biomolecules to interpretation cellular communication systems K_U02 U3: Student interprets correctly obtained results K_U07 U4: Student draws the final conclusions and can prepare reports, laboratory documentation and expert presentations K_U08 U5: Student demonstrates the ability to use basic literature sources. K_U11

Learning outcomes - social competencies

K1: Student understands that the lifelong learning is the ongoing, voluntary and self-motivated pursuit of knowledge K_K01, K2: The student rationally and critically refers to literature data K_K03, K3: Student can critically evaluate the obtained results, is aware of the responsibility of his eveluation K_K07, K4: Student adheres to the principles of work, is responsible is responsible for the equipment entrusted to him, his own work and others K_K10

Teaching methods

zna zakres działania, uprawnienia i obowiązki służb BHP w zakładzie pracy oraz ich praktyczne uwarunkowania

Expository teaching methods

- informative (conventional) lecture

Exploratory teaching methods

- laboratory

Type of course

compulsory course

Course coordinators

Joanna Czarnecka
Adriana Szmidt-Jaworska

Assessment criteria

Lecture – summative assessment of knowledge
K_W01, K_W02, K_W04, K_W05
Laboratory classes – summative assessment of knowledge
K_W01, K_W02, K_W04, K_W05
Summative assessment of skills and competencies
K_U01, K_U02, K_U07, K_U08, K_U11, K_K01, K_K03, K_K07, K_K10

Assessment criteria
Lecture component: A prerequisite for completing the lecture component is successful completion of the laboratory course associated with the subject and attendance at the lectures. Accepted forms of assessment include: single-choice test, multiple-choice test, and open-ended questions.
Grading thresholds: pass: 55–60%, pass plus: 61–70%, good: 71–80%, good plus: 81–90%, very good: 91–100%

Laboratory classes:
A prerequisite for completing the laboratory course is attendance at all classes. Assessment components include: written report covering the topics addressed during the course (70%), continuous assessment (ongoing preparation for classes and written reports, 20%), and active participation (10%).
Grading thresholds: pass: 55–60%, pass plus: 61–70%, good: 71–80%, good plus: 81–90%, very good: 91–100%

Practical placement

not applicable

Bibliography

1. Alberts B, et al. (2014), Essential Cell Biology, Garland Science
2. Stryer L, Tymoczko JL, Berg JM (2015) WH Freeman

Facultative literature
3. Gomperts BD, et al. (2009) Signal transduction, Academic Press,
4. Hancock J. (1997) Cell signalling, Prentice Hall, 1997

Additional information

Additional information (registration calendar, class conductors, localization and schedules of classes), might be available in the USOSweb system:

Description of 2600-BK-CCBIOL-1-S2 in USOSweb