Drug Chemistry 1709-F3-CHLE-J

The Drug Chemistry course is implemented in the form of lectures, exercises, and laboratory classes.
Lectures aim to provide knowledge in the field of nomenclature and classification of drugs within the pharmacological–therapeutic–chemical (ATC) system, as well as their mechanisms of action and biotransformation.
The lectures are intended to teach knowledge about drugs acting on the peripheral nervous system, adrenergic drugs, adrenolytic drugs, cholinolytic drugs, skeletal muscle relaxants, drugs acting on the central nervous system, neuroleptics, antidepressants, anxiolytics, hypnotics and sedatives, surgical anaesthetics, analgesics – narcotic and non-steroidal anti-inflammatory drugs (NSAIDs), antiepileptic drugs, central nervous system stimulants, and drugs used in Alzheimer’s and Parkinson’s diseases.
The programme also includes drugs acting on the cardiovascular system. Within the scope of knowledge, the student knows the basic pharmacological classification of drugs, the chemical and biochemical mechanisms of drug action, and is able to explain the relationship between chemical structure and drug activity.
Exercises are intended to teach knowledge in the field of drug nomenclature and classification, drug dependence, adverse and toxic effects, as well as the characteristics of the main groups of drugs.
A student attending laboratory classes knows and understands the methods used for qualitative and quantitative assessment and is therefore able to perform quality control of medicinal substances and to select an appropriate analytical method, including validation, for a given purpose.
Laboratory classes aim to teach knowledge in the field of basic pharmacopoeial methods used in the quantitative and qualitative analysis of medicinal substances.

Term 2022/23Z:

None

Term 2023/24Z:

None

Term 2024/25Z:

None

Term 2025/26Z:

According to the Drug Chemistry subject syllabus.

Total student workload

1) The student workload related to classes requiring direct participation of academic teachers amounts to: − participation in lectures: 55 hours, − participation in exercises: 50 hours, − participation in laboratory classes: 145 hours, − completion of the credit and examination: 4 hours. The total student workload related to classes requiring direct participation of academic teachers amounts to 254 hours, which corresponds to 10.16 ECTS credits. 2) Balance of student workload: − participation in lectures: 55 hours, − participation in exercises: 50 hours, − participation in laboratory classes: 145 hours, − prior preparation and completion of notes: 30 hours, − collection and selection of appropriate materials for classes: 30 hours, − required review of the material: 20 hours, − reading of the indicated literature: 36 hours, − preparation for exercises: 18 hours, − preparation for colloquia: 20 hours, − preparation for credit/examination + credit/examination: 20 + 4 = 24 hours. The total student workload amounts to 375 hours, which corresponds to 15 ECTS credits. 3) Workload related to conducting scientific research: − reading of the indicated scientific literature: 30 hours, − participation in lectures (including methodology of scientific research, research results, studies): 40 hours, − participation in exercises (including methodology of scientific research, research results, studies): 35 hours, − participation in laboratory classes (including methodology of scientific research, research results, studies): 100 hours, − preparation for credit in the scope of research and scientific aspects of the implemented subject: 12 hours. The total student workload related to conducting scientific research amounts to 217 hours, which corresponds to 8.68 ECTS credits. 4) Time required for preparation and participation in the assessment process: − preparation for exercises: 18 hours (0.72 ECTS credit), − preparation for colloquia: 20 hours (0.8 ECTS credit), − preparation for credit and examination + credit and examination: 20 + 4 = 24 hours (1 ECTS credit). 5) Time required to complete the compulsory internship(s): − not applicable.

Learning outcomes - knowledge

W1: knows the chemical and biochemical mechanisms of drug action – K_C.W1 W2: knows the physicochemical properties of medicinal substances affecting the biological activity of drugs – K_C.W2 W3: classifies medicinal substances according to the Anatomical Therapeutic Chemical (ATC) classification system or pharmacological system, taking into account international and synonymous names – K_C.W3 W4: knows radiolabelled drugs and isotopically labelled compounds used in the diagnosis and therapy of diseases, methods of their preparation, and properties – K_C.W4, K_C.W7 W5: knows classical and instrumental methods used in the assessment of the quality of substances for pharmaceutical purposes and in the quantitative analysis of medicinal products – K_C.W5, K_C.W6, K_C.W8, K_C.W9

Learning outcomes - skills

U1: is able to explain the relationship between the chemical structure and the activity of drugs of different classifications – K_C.U1, K_C.U3 U2: performs quality control of substances for pharmaceutical purposes and of drugs in accordance with pharmacopoeial requirements; applies appropriate analytical methods in pharmaceutical studies and carries out analytical method validation – K_C.U5, K_C.U6, K_C.U8 U3: based on the structure and activity of radiopharmaceuticals, is able to indicate their applications in medicine – K_C.U2 U4: using pharmacopoeial monographs, is able to perform qualitative and quantitative analysis of a pure medicinal substance and its extraction from a drug form – K_C.U1 U5: evaluates the results obtained in the scope of quality testing of substances for pharmaceutical purposes and confirms their compliance – K_C.U7

Learning outcomes - social competencies

K1: draws and formulates conclusions from own measurements and observations – K8

Teaching methods

Lectures: − informative (conventional) lecture − problem-based lecture with multimedia presentation Laboratory: − laboratory and practical classes − teamwork and individual work − measurement and analysis of results − verification of students’ knowledge (written form or oral response) Exercises: − classroom exercises with multimedia presentation − conversational lecture − teamwork and individual work

Prerequisites

To undertake the described course, students are required to have basic knowledge of inorganic and analytical chemistry, organic chemistry, and physiology in the scope related to the properties of chemical compounds. In addition, students attending the course should possess knowledge and skills acquired within the following subjects: biophysics, mathematics, and statistics.

Course coordinators

Michał Marszałł

Assessment criteria

Written exam (test): (lecture material) Only students who have obtained credits for exercises and laboratory classes are admitted to the exam.
The exam consists of 100 multiple-choice test questions. Each question is worth 0.3 points. Maximum number of points from the test - 30 points.
Satisfactory: 18.00–19.00 points
Satisfactory Plus: 20.00–22.00 points
Good: 23.00–25.00 points
Fairly good: 26.00–28.00 points
Very good: 29.00–30.00 points
The total number of points obtained in the exam includes additional bonus points gained from written control tests (lecture-based).
Lectures: (lecture material) The colloquium consists of 36 single-choice test questions. Each question is worth a maximum of 0.25 points.
For each colloquium with a result of at least 5 points, the student receives an additional 1 point, added to the final pool of exam points.
A total of four colloquia are scheduled (a maximum of 4 bonus points can be obtained).

Exercises: (exercise material) Two colloquia are held in the form of single-choice tests, according to the schedule presented in the syllabus for the Pharmacy programme (5th semester – winter semester).
Each colloquium consists of 30 questions, with a maximum of 1 point per question.
The maximum number of points from one test is 30 points.
To pass the colloquium, students must achieve at least 60% (18 points).
During classes carried out in the winter semester, there are four written introductory tests (entrance tests) in the form of a single-choice test. Passing the entrance test gives the student additional percentage points for the colloquium result. Passing one entrance test increases the colloquium result by 5%, while passing two entrance tests increases the colloquium result by 10% in a given thematic block. The teacher decides on the course of colloquiums and entrance tests.

Laboratory: (laboratory material) Two written colloquia per semester are conducted according to the thematic schedule presented in the syllabus for the Pharmacy programme (5th semester – winter semester and 6th semester – summer semester).
Their detailed organization is determined by the teacher. The maximum number of points from each test is 30 points. To pass, students must obtain at least 60% (18 points).

A condition for obtaining the final laboratory credit is the correct identification and/or quantitative analysis of all tested preparations and the successful completion of all colloquia.

Practical placement

The educational program does not provide for professional internships.

Bibliography

1. Instant Notes Medicinal Chemistry, G.Patrick, 2001, Taylor&Francis Group
2. An Introduction to Medicinal Chemistry, G.Ptrick, 2009, Oxford.

Term 2022/23Z:

None

Term 2023/24Z:

None

Term 2024/25Z:

None

Term 2025/26Z:

According to the Drug Chemistry subject syllabus.

Additional information

Additional information (registration calendar, class conductors, localization and schedules of classes), might be available in the USOSweb system:

Description of 1709-F3-CHLE-J in USOSweb