Pharmacokinetics 1705-F3-FKIN-J

Pharmacokinetics course concerns the knowledge and practical skills essential in understanding the kinetic processes of drug is subjected to in organism i.e. release, absorbing, distribution, biotransformation and excretion.
The lectures provide a knowledge on distribution law and compartment theory of therapeutic substance based on hydrodynamic analogues as well as understanding of terms such as biological half-life, distribution capacity, bioavailability, organ clearance and total body clearance.
Students will be acknowledged about pharmacokinetics of intravascular and extravascular drug administration in single and double compartment delivery model, pharmacokinetics of multiple drug delivery, the notion of a steady-sate concentration and its description, and pharmacokinetics of intravenous infusion.
They will be also acknowledged about the problems concerning the assessment of pharmacokinetic parameters based on mass of drug found in excreted urine and about the assessment of basic pharmacokinetic parameters using non compartment model technique. They will be also presented the nonlinear pharmacokinetics.
Lectures will familiarize participants with physiological model of pharmacokinetics and problems of pharmacokinetics based on measurement of drug concentration in the body.
Lab exercises are to some extent bond with the topics of lectures. Their aim is to acknowledge students with analytical techniques essential to conducting the determined research goal. They will allow students to conduct exercises using HPLC techniques and spectroscopic analysis on their own.
There are also used computer programs that allow the students to conduct sophisticated calculations based on data gathered during the class.
Laboratory classes allow to develop competences of effective work organization and teamwork.

Total student workload

1. Obligatory hours realized with the teacher participation - Lectures participation – 10 hours - Tutorials participation – 25 hours - Consultations participation – 2 hours - Final test participation – 2 hours Total obligatory hours realized with the teacher participation: 39 hours, which corresponds to 1.56 ECTS points. 2. Student workload balance: - Lectures participation – 10 hours - Tutorials participation – 25 hours - Preparation for laboratories – 7 hours - Reading the indicated literature – 7 hours - Preparation of lab reports – 7 hours - Consultations participation – 2 hours - Final test preparation and test participation – 15 + 2 = 17 hours A total work amount: 75 hours, which corresponds to 3 ECTS points. 3. Workload related to conducting research: - Reading scientific literature – 4 hours - Research and scientific consultation participation – 1 hour - Lectures (including methodology of research, results, and reports) participation – 6 hours - Laboratory (including methodology of research, results, and reports) participation – 14 hours - Preparation for laboratory that includes scientific activity – 5 hours - Preparation for final test that includes scientific and research activity in the field of pharmacokinetics – 8 hours - Preparation of laboratory course report on scientific research in pharmacokinetics – 7 hours A total work amount of scientific research activity: 45 hours, which corresponds to 1.8 ECTS points. 4. Time required for the preparation and participation in evaluating process: - Preparation for laboratory class + preparation for final test + final test: 7 + 15 + 2 = 24 hours (0.96 ECTS points) 5. Time required for the practical training completion – not applicable

Learning outcomes - knowledge

W1: Uses pharmacokinetic parameters to describe the kinetics of drug-related processes in the body - K_D.W4, K_ D.W5 W2: Uses compartmental theory to describe pharmacokinetic processes determining dose-concentration-time relationships - K_D.W5 W3: Predicts the effect of intrinsic and extrinsic factors on the course of drug pharmacokinetic processes in the body - K_D.W6 W4: Explains the term of bioavailability and the parameters characterizing it - K_D.W9 W5: Substantiates the use of drug concentration-monitored therapy - K_D.W8

Learning outcomes - skills

U1: Can calculate the pharmacokinetic parameters of the drug describing the kinetics of the processes that the drug undergoes in the body - K_D.U2, K_D.U3, K_D.U6 U2: Is able to carry out and interpret the drug bioavailability study - K_D.U4 U3: Is able to plan the change of drug dosage in an individual patient based on the influence of intrinsic and extrinsic factors and on the basis of monitored drug concentration in the blood - K_D.U12

Learning outcomes - social competencies

K1: Demonstrates the conclusions drawn from the measurements and observations made - K8 K2: Demonstrates the ability to work in a team - K3

Teaching methods

Lecture: - Informative lecture with the elements of multimedia presentation - Conversation lecture Practicals: -Laboratory classes, - Didactic discussion with the elements of multimedia presentation - Computer-assisted learning

Type of course

compulsory course

Prerequisites

Basic knowledge on biology, physicochemistry, biochemistry, mathematics and statistics.

Course coordinators

Term 2024/25L:

Adam Buciński
Urszula Marzec-Wróblewska

Term 2025/26L:

Adam Buciński
Urszula Marzec-Wróblewska

Term 2022/23L:

Adam Buciński

Term 2023/24L:

Adam Buciński

Assessment criteria

Lectures
A written test containing open and test questions: W1-W5, U3.
Positive grades >60% of points.

Laboratories
A written test containing open questions : W1, W2, W4, U1, U2.
Positive grades >60% of points.
Properly conducting laboratory exercises and providing the reports on their results, continuous assessment of current preparation for classes and student activity: K1, K2, U1
Grade:
92% - 100% - Excellent (5)
84% - 91% - Very good (4.5)
76% - 83% - Good (4)
68% - 75% - Satisfactory (3.5)
60% - 67% - Acceptable (3)
0% - 59% - Fail (2)
Obtaining credit for lectures and laboratory classes is a condition for passing the subject.
Final grade
The final grade is the average of the grades obtained:
4,75 - 5,00 Excellent (5)
4,25 - 4,74 Very good (4.5)
3,75 - 4,24 Good (4)
3,25 - 3,74 Satisfactory (3.5)
2,75 - 3,24 Acceptable (3)
0 - 2,74 Fail (2)

Bibliography

Primary literature:
1. Leon Shargel, Andrew B. C. Yu, Applied Biopharmaceutics & Pharmacokinetics, Seventh Edition, McGraw-Hill United States, 2016
2. Malcolm Rowland , Thomas N. Tozer, Clinical Pharmacokinetics and Pharmacodynamics : Concepts and Applications, Lippincott Williams and Wilkins, Philadelphia, 2010
3. Ashutosh Kar, Essentials of Biopharmaceutics and Pharmacokinetics- E-Book, Elsevier Health Sciences, 2010
4. Thomas N. Tozer, Malcolm Rowland , Introduction to Pharmacokinetics and Pharmacodynamics : TheQuantitative Basis of Drug Therapy, Lippincott Williams and Wilkins, Philadelphia, 2006
5. Recommended papers from scientific journals.

Supplementary literature:
1. Thomas N. Tozer, Malcolm Rowland, Essentials of Pharmacokinetics and Pharmacodynamics, Lippincott Williams and Wilkins, Philadelphia, United States, 2015
2. Michael E. Winter, Basic Clinical Pharmacokinetics, Fourth Edition, Lippincott Williams and Wilkins, Philadelphia, United States, 2004
3. Donald J. Birkett, Pocket Guide: Pharmacokinetics Made Easy, McGraw-Hill Education, Australia, 2011

Additional information

Additional information (registration calendar, class conductors, localization and schedules of classes), might be available in the USOSweb system:

Description of 1705-F3-FKIN-J in USOSweb