(in Polish) Applications of carboxylic acids and their derivatives in pharmacotherapy 1700-OG-EN-NDAiCMS

Lectures
Basic concepts and definitions: anatomical-therapeutic-chemical classification of selected molecules, bioisosterism, hydrophilicity and lipophilicity, pH of acids and their derivatives.
Discussion of the spatial structure and chemical nomenclature of selected molecules in accordance with their anatomical, therapeutic and chemical classification. Derivatives of carboxylic acids by isosteric substitution of the carboxyl group exhibiting different or opposite pharmacology in relation to the parent carboxylic acids (e.g. baclofen, falkofen and salkofen).
History of the discovery of basic pharmaceuticals such as salicylic acid, aspirin, paracetamol and others.
A summary and comparison of the chemical, physical and biological properties of acids and their derivatives that determine their therapeutic and toxicological effects. Analysis of the pH range of body fluids (e.g. saliva, blood) and organs (e.g. stomach, intestines) and the bioavailability of chemicals.

Total student workload

1. The workload associated with classes requiring the direct participation of academic teachers is: – participation in lectures: 15 hours. The workload associated with classes requiring the direct participation of academic teachers is 15 hours, which corresponds to 0.6 ECTS points. 2. Student workload balance: – participation in lectures: 15 hours – preparation for classes, including reading selected literature: 5 hours – preparation for assessment and assessment: 5 hours. The total workload associated with the course is 25 hours, which corresponds to 1 ECTS credit. 3. Student workload balance related to scientific activity conducted at the university: 25 hours, which corresponds to 1 ECTS credit. 4. Student workload balance of a practical nature: Not applicable

Learning outcomes - knowledge

W1: Has specialist knowledge of the principles of designing new drugs for specific structural properties W2: Has knowledge of modern synthesis methods used in drug design

Learning outcomes - skills

U1: Has the ability to select suitable candidates for drugs based on the steric profiles of chemical compounds U2: Has the ability to properly select synthesis methods in the design of drugs with selected therapeutic properties

Learning outcomes - social competencies

K1: understands the need for continuous professional development

Teaching methods

Lectures: - informative lecture (conventional) - problem lecture with multimedia presentation

Expository teaching methods

- informative (conventional) lecture
- problem-based lecture

Type of course

elective course

Prerequisites

Students should have basic knowledge of the properties of chemical compounds obtained through courses in organic chemistry, physical chemistry, and analytical chemistry.

Course coordinators

Łukasz Fijałkowski
Alicja Nowaczyk

Assessment criteria

Lecture: Pass mark based on a written assignment on a selected topic - W1, W2, U1, U2.
The points obtained are converted into grades according to the following scale:

Percentage of points Grade
92-100% Very good
84-91% Good plus
76-83% Good
68-75% Satisfactory plus
60-67% Satisfactory
0-59% Unsatisfactory

Practical placement

not applicable

Bibliography

Required reading:
1. A.K. Smakosz, Historia medycyny i farmacji: szkice i eseje Pharmacopola, Wrocław 2022
2. Kroszczyński, W. (2017). Krótka historia niektórych wzorów związków organicznych. Ridero IT Publishing.
3. R. Rembieliński B. Kuźnicka, Historia farmacji, PZWL, Warszawa 1987

Supplementary reading:
1. Montinari, M. R., S. Minelli and R. De Caterina (2019). "The first 3500 years of aspirin history from its roots–A concise summary." Vascular pharmacology 113: 1-8..
2. Brune, K., Renner, B., & Tiegs, G. (2015). Acetaminophen/paracetamol: a history of errors, failures and false decisions. European Journal of Pain, 19(7), 953-965.
3. Ballatore, C., Huryn, D. M., & Smith III, A. B. (2013). Carboxylic acid (bio) isosteres in drug design. ChemMedChem, 8(3), 385-395.

Additional information

Additional information (registration calendar, class conductors, localization and schedules of classes), might be available in the USOSweb system:

Description of 1700-OG-EN-NDAiCMS in USOSweb