Modern Methods of Genetic Diagnostics 1655-Lek3DIGE-J

(in Polish) 1. The workload related to the classes requiring the direct participation of academic teachers is: - participation in lectures: 4 hours - participation in seminars: 6 hours - participation in exercises: 0.5 hours - consultation: 0.5 hour - completion of the test: 0.5 hour The workload related to the activities requiring the direct participation of academic teachers amounts to 11 hours, corresponding to 0.44 ECTS points 2. Balance of student workload: - participation in lectures: 4 hours - participation in seminars: 6 hours - consultation: 0.5 hour - preparation for the seminar (including reading the indicated literature): 9.5 hours - preparation for exercises (including reading the indicated literature): 12 hours - preparation for passing and passing: 9 + 0.5 = 9.5 hours The total student workload is 13.5 hours, which corresponds to 0.54 ECTS points 3. Workload related to the conducted research: Not applicable 4. Time required to prepare for and participate in the assessment process: - preparation for the test: 9 + 0.5 = 9.5 hours (0.38 ECTS points) 5. Balance of student workload of a practical nature: - participation in seminars: 6 hours - preparation for the seminar (including reading the indicated literature): 6 hours; 0.24 ECTS The total student workload of a practical nature is 6 hours, corresponding to 0.24 ECTS points 6. Time required for compulsory internship: not applicable

(in Polish) Student: W1: Characterizes new genetic and epigenetic biomarkers in oncology, introduced for diagnosis or clinical trials; qPCR methods, MLPA capillary sequencing (C.W7, C.W9, C.W.41, E.W.24, E.W.39). W2. Characterizes liquid biopsy and genetic biomarkers for therapy monitoring (circulating tumor cells, circulating DNA, exosomes, miRNAs (C.W11, C.W9, C.W.41, C.W.42, E.W.25, E.W.39). W3. Discusses high-throughput diagnostic methods as tools for detecting constitutive and somatic changes (microarrays, next-generation sequencing, including WES) (C.W9, C.W11, C.W.24, C.W.41, C.W.42, E.W.39); W.4 Discusses international standards for interpreting next-generation sequencing results (C.W.41, E.W.37); automation of diagnostic processes and the use of panels/molecular profiles

(in Polish) Student: U1. Correctly distinguishes examinations in the detection of somatic versus constitutive changes; He can evaluate the value of tests using new technologies such as qPCR, NGS, microarrays, MLPA in the diagnostic process. knows how to plan the collection of appropriate material for research, including material for monitoring genetic changes related to the acquisition of drug resistance by cancer cells (E.U16, E.U24, E,U28). U2. Can decide on the need to perform tests to monitor therapy using new technologies (E.U16) U3. knows international standards for interpreting next-generation sequencing results, understands the concepts of VUS; pathogenic lesion, possibly pathogenic lesion, likely benign lesion, and benign lesion (stage I-V, scale I-IV);

(in Polish) Student: K_K06. implementing the principles of professional camaraderie and cooperation in a team of specialists, including representatives of other medical professions, also in a multicultural and multinational environment K_K07. noticing and recognizing one's own limitations and self-assessing deficits and educational needs in the field of genetic research and updating interpretations, the importance of innovative molecular biology techniques in oncological genetics

(in Polish) Lectures: • informative lecture with the possibility of discussion Seminars: • seminars and multimedia presentations• assisted learning with a multimedia presentation • method of didactic discussion • case studies Tutorials: • instructional demonstration • subject exercises • simulation methods (case study; simulated patient)

- problem-based lecture
- participatory lecture

- seminar
- case study

(in Polish) A student commencing education in the field of Modern Methods of Genetic Diagnostics should have knowledge of the basics of medical genetics and molecular biology

Additional information (registration calendar, class conductors, localization and schedules of classes), might be available in the USOSweb system:

• Description of 1655-Lek3DIGE-J in USOSweb