At the Border of Chemistry and Biology 0600-S2-PP/NS-CB
Lecture:
1. Important Nobel Prizes in chemistry and medicine. 1h
2. Inorganic compounds, including coordination compounds in the atmosphere, hydrosphere, and Earth surface. 1h
3. Natural and human-made chelating ligands. Their structure, importance, and activity. 1h
4. The role of coordination compounds in preserving the environment, hydrosphere, and atmosphere. 1h
5. Toxic metals and their complexes. 1h
6. Biomineralization. 1h
7. The role of metalloenzymes in non-redox and redox mechanisms of catalysis. 1h
8. Binding, transport, and storage of metals. Transport of oxygen (hemoglobin, hemerythrin, hemocyanin). 1h
9. Chlorophylls and bacteriophylls as the most significant photoreceptors in nature. 1h
10. Nitrogen-binding enzymes. 1h
11. Metal carcinogenesis, oxidative stress, and their effects. 1h
12. Metal compounds in biochemical imaging. 1h
13. The role of metal ions in the development of neurodegenerative diseases. 1h
14. Coordination compounds in personalized medical therapy (cancer, immune diseases). 1h
15. Biosensors of metal ions. 1h
Laboratory:
1. Synthesis and characterization of compounds of therapeutic importance: - compounds used in RA - inhibitors of the tyrosine phosphatase enzyme.
2. Salicylic acid and its complexes.
3. Photocatalytic processes in the environment. Synthesis and characterization of selected compounds of Fe(III), Cu(II), Cr(III), and Cr(VI).
4. Determination of stability constants of copper(II) complexes with selected amino acids.
5. Effect of pH on the binding mode of copper(II) by glycylglycine in an aqueous solution.
6. The role of metals in dopamine oxidation. Neurodegenerative diseases.
7. Chlorophyll as a model system of a biological molecule.
Total student workload
Learning outcomes - knowledge
Learning outcomes - skills
Learning outcomes - social competencies
Teaching methods
Type of course
Prerequisites
Course coordinators
Learning outcomes
W1: Student has in-depth knowledge of the fundamental departments of chemistry, its development, and importance for the progress of exact and natural sciences as well as cognition of the world and human development -K_W01
W2: Student has in-depth knowledge in the selected field of chemistry - K_W01
U1: Student can use in-depth knowledge from various departments of chemistry and creatively use it in the field of his specialty-K_U01
K1: Student is aware of professionalism, appreciates intellectual honesty, and observes professional ethics, both in the activities of their own and others - K_K06
K2: Student can formulate and present opinions on fundamental chemical issues and achievements in this discipline - K_K07
Assessment criteria
Assessment methods:
- written examination -W1, W2
- preparation for practical sessions - W2, U1, K1, K2
- written reports – W2, K2, U1
Assessment criteria:
fail- 0-49%
satisfactory- 50-60%
satisfactory plus- 61-65%
good - 66-75%
good plus- 76-80%
very good- 81-100%
Practical placement
Not applicable
Bibliography
1. M. Cieślak-Golonka, J. Starosta, A. Trzeciak, „Chemia koordynacyjna w zastosowaniach”, PWN 2017;
2. Z. Stasicka, G. Stochel, „Podstawy i perspektywy chemii koordynacyjnej”, Uniwersytet Jagielloński 2017;
3. P. Atkins, T. Overton i in., Shriver&Atkins Inorganic Chemistry, 5 wyd. Oxford University Press 2010;
4. C. E Housecroft, A. G. Sharpe, Inorganic Chemistry, 5th ed., Pearson Education Limited, 2018;
5. J. R. Gispert, “Coordination Chemistry”, Wiley-VCh 2008;
6.S.J. Lippard, J.M. Berg, Podstawy chemii bionieorganicznej, PWN, Warszawa, 1998.
7. R. Hay, Chemia bionieorganiczna, PWN Warszawa, 1990.
8. Selected articles published in Journal of Chemical Education, and Coordination Chemistry Reviews.
Additional information
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