Chemical technology of pharmaceuticals 0600-S2-CM-TCL

Lecture: Catalysis and catalytic processes: homogeneous, heterogeneous and biocatalysis; selectivity and catalytic activity; heterogeneous catalyst - -composition (active phase, carrier, activators).
Design of technological processes: stages of development of a chemical process, scaling up of synthesis (role of reagents, catalysts, solvents, temperature, by-products). Laboratory scale and quarter- and semi-technical scale. Basic principles of designing a production process (minimizing the number of stages, convergent and linear synthesis, minimizing chemical hazards). Excipients
in pharmaceutical technology, requirements for excipients, fillers (soluble and insoluble in water), binders, lubricants and coatings.
Unit physical processes, change of scale of the technological process. Chemical technology of medicinal products - discussion of preliminary schemes of selected medicinal products.
Industrial production and purification of salicylic acid. Mass balance and Sankey diagram for this process. Application of salicylic acid and its derivatives. Mechanism of acetylation of the hydroxyl group of salicylic acid using acetic anhydride. Synthesis of polopiryne in laboratory conditions.
Sodium bicarbonate as a drug - industrial and laboratory production, analysis. Properties, application and production of barium sulfate (VI). Properties and synthesis of paracetamol, as an example of NSAIDs. Production and properties of nicotinic acid and its amide (vitamin PP, B3). Production of Cholamide (N-hydroxymethylamide of nicotinic acid)
Laboratory: During laboratory exercises, students perform the synthesis and determine the properties of auxiliary compounds and medicinal agents. Production and evaluation of physicochemical properties of NaHCO3. Kinetics of paracetamol release. Study of quality parameters of simple granulates: part 1 - Preparation of selected granulates, part 2 - Study of quality parameters of granulates.
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Total student workload

1. Hours implemented with the participation of teachers: contact hours: 65h - 10h lecture, 30h laboratory - consultations with an academic teacher: 25h 2. Time devoted to individual work: 15h 3. Time required to prepare and participate in the assessment process: 20h Total: 100h / 25 = 4 ECTS

Learning outcomes - knowledge

W1: knows the physicochemical properties of compounds used in the synthesis of drugs W2: knows the methods used to obtain the drug. W3: knows selected technological processes and devices used in the technology of drug production W4: knows the operations and unit processes used in the production of drugs, the principles of green chemistry, and waste management. W5: knows the methods used to assess the quality of the drug. K_W01, K_W02, K_W03, K_W04

Learning outcomes - skills

U1: can select the conditions for the production of selected drugs U2: can propose a drug synthesis based on selected operations and unit processes used in the production of drugs U3: can propose the appropriate reagents and the appropriate method of their disposal U4: can select process parameters to obtain the appropriate efficiency U5: is able to use the appropriate methods for the qualitative assessment of the drug K_U01, K_U03

Learning outcomes - social competencies

K1: can work independently and organize work effectively K2: sees a problem and can solve it K3: can set priorities appropriately to plan and implement a specific task K4: is able to cooperate in a team K_K01, K_K03

Teaching methods

Lecture: conventional, informative with the use of multimedia presentations - method of giving Laboratory: didactic methods seeking: independently conducting experiments simulating selected processes, classic problem method

Expository teaching methods

- informative (conventional) lecture

Exploratory teaching methods

- experimental
- laboratory

Type of course

compulsory course

Prerequisites

Basic knowledge of organic chemistry, analytical chemistry, instrumental analysis

Course coordinators

Marcin Cichosz
Urszula Kiełkowska

Assessment criteria

Lecture: written exam (multiple choice and open questions) – W1-W5, U2, K2
Includes content presented in lectures
Laboratory: graded credit – W1-W5, U1-U5, K1-K4
continuous student assessment during classes (participation in classes, commitment, conscientiousness, preparation for classes)
During the laboratory, students pass a colloquium on the material covered in the laboratories and present reports from the experiments performed along with a summary and discussion of the results.
Assessment criteria:
Thresholds are assessed in accordance with the UMK regulations
required threshold for a satisfactory grade - 50-60%, satisfactory plus – 61-65%, good 66-75%, good plus 76-81%, very good – 82-100%

Bibliography

1. G. L. Patrick, Chemia medyczna, WNT, Warszawa, 2003.
2. T. Tkaczyński, D. Tkaczyńska Synteza i technologia chemiczna leków, PZWL 1984.
3. A. I. Vogel Preparatyka organiczna, WNT, Warszawa 2009.
4. S. Biniecki, Preparatyka środków leczniczych. PZWL, Warszawa 1983.
Literatura uzupełniająca:
Douglas S. Johnson, Jie Jack Li, The Art of Drug Synthesis, Wiley, 2007

Additional information

Additional information (registration calendar, class conductors, localization and schedules of classes), might be available in the USOSweb system:

Description of 0600-S2-CM-TCL in USOSweb