Materials for the needs of modern personalized implantology 0600-S2-CM-MNiS

The subject includes a ten-hour lecture and a thirty-hour laboratory. The lecture will present concepts and definitions related to implantology and regenerative medicine. Topics related to modern trends in implantology will be discussed, including personalization of implants using additive methods ("3D printing"), such as selective laser sintering - SLS, selective laser melting - SLM and traditional - milling, using metal powders, composites and polymers. Materials, biomaterials and nanomaterials for the needs of orthopedic implantology and maxillofacial surgery, dentistry, cardiological implantology, cardiosurgery, urology and neurological and neurosurgical implantology will be discussed. During the laboratory classes, 5 six-hour exercises will be conducted, covering issues related to: analysis of the composition, structure and morphology of titanium and titanium alloy implants manufactured using various methods (SLS, SLM, milling), modification of the surface of titanium alloy implants using electrochemical oxidation methods (production of titanium dioxide nanotubes) and cathodic electrodeposition (production of a hydroxyapatite coating), and enrichment of the surface of titanium alloy implants with metallic and oxide nanoparticles using the chemical vapor deposition method and the atomic layer growth method. As part of the laboratory work, students will be familiarized with methods for measuring the biological activity of the surface of titanium alloy implants, unmodified and surface-modified (biocompatibility, biocompatibility, antibacterial) and with the analysis of their mechanical properties, wettability and photocatalytic activity. An additional asset will be a case study of the academic company Nano-implant, in order to familiarize oneself with the technology of 3D printing of a personalized implant (prototyping, printing of a polymer model, printing in metal).

Total student workload

Participation in lecture - 10h Participation in laboratory - 30h Participation in consultations - 25h Own work - 35h Total student workload: 100h (4 ECTS points)

Learning outcomes - knowledge

W1: has extended knowledge of the basic areas of materials and nanomaterials chemistry, its development and significance for the progress of exact and natural sciences and for the understanding of the world and the development of humanity – K_W01; W2: has knowledge of methods for the analysis of the structure, morphology and biological properties of materials and nanomaterials - K_W01 W3: has knowledge of the synthesis and characterization of oxide and metallic coatings/thin films on metal and metal alloy surfaces – K_W03; W4: has knowledge of trends in the production of modern materials for the needs of modern implantology - K_W04 W5: has knowledge of the procedures for introducing a medical product to the market (the need to perform clinical trials and certification) - K_W02

Learning outcomes - skills

U1: is able to use extended knowledge in the field of inorganic, organic chemistry, materials and biomaterials chemistry and creatively use it in the field of biomedical chemistry - K_U01 U2: is able to independently plan the synthesis of a material with the desired structure, morphology and optimal biological properties for application purposes in implantology - K_U05; U3: is able to independently search for information in scientific and popular science journals and chemical databases in Polish and English; formulates scientific problems in the field of chemistry, seeks their solutions, presents the results of work in the form of written reports in Polish and a foreign language and in the form of an independently prepared paper - K_U05;

Learning outcomes - social competencies

K1: knows the limitations of one's own knowledge and understands the need for further lifelong learning; is able to independently take action to expand and deepen chemical knowledge - K_K01 K2: is able to cooperate in a team (taking on different roles in it) and creatively solve problems related to scientific research and chemical synthesis - K_K02 K3: is ready to fulfill a professional role taking into account changing social needs - K_K03

Teaching methods

Lecture: Lecture combined with discussion, supported by audio-visual methods Laboratory: Performance of planned laboratory exercises, discussion, independent work.

Expository teaching methods

- informative (conventional) lecture
- problem-based lecture

Exploratory teaching methods

- laboratory

Type of course

compulsory course

Prerequisites

Basic knowledge of medicinal chemistry, materials chemistry, biomaterials chemistry, inorganic and analytical chemistry, organic chemistry and physical chemistry.

Course coordinators

Aleksandra Radtke

Assessment criteria

Lecture - written exam
The assessment is based on knowledge and skills through a written exam - test - within the scope of the following learning outcomes: W1, W2, W3, W4, W5, U1, U2, U3.

Laboratory - sum of points collected during the performance of 5 laboratory exercises; reports from classes are assessed, which include, in addition to the description of the experiment, also a theoretical paper on a topic assigned by the instructor; scope of the following learning outcomes: W1, W2, W3, W4, W5, U1, U2, U3, K1, K2, K3.

Practical placement

No internships are planned

Bibliography

Advances in Materials Science and Implant Orthopedic Surgery, Edited by R Kossowsky, Dr. Nir Kossovsky
Surface Engineering: Surface Modification of Materials, Edited by R Kossowsky, S C Singhal
Marek Wyleżoł, Barbara Ostrowska, Eliza Wróbel Małgorzata Muzalewska, Marcin Grabowski Dominik Wyszyński, Jarosław Zubrzycki, Piotr Przech, Tomasz Klepka, Inżynieria biomedyczna Metody przyrostowe w technice medycznej, Monografie Politechnika Lubelska, Lublin 2016
Polymers for Dental and Orthopedic Applications, Edited by Shalaby W. Shalaby, Ulrich Salz
Bone Implant Grafting edited by John Older
Magnesium Alloys as Degradable Biomaterials, Edited byYufeng Zheng
Hydroxyapatite Coatings for Biomedical Applications, Edited by Sam Zhang
Biomaterials Science: An Integrated Clinical and Engineering Approach, Edited by Yitzhak Rosen, Noel Elman
Orthopaedic Biomaterials in Research and Practice, Edited by Kevin L. Ong, Scott Lovald, Jonathan Black

Additional information

Additional information (registration calendar, class conductors, localization and schedules of classes), might be available in the USOSweb system:

Description of 0600-S2-CM-MNiS in USOSweb