Chemistry of bioorganic and heterocyclic compounds 0600-S2-CM-CBO

Lecture:
Monosaccharides, disaccharides and deoxysugars – structure, properties, reactions. Lipids: terpenes and steroids – structure, biosynthesis, properties. Alkaloids, main groups and their properties. Amino acids, structure, peptide bond, reactions. Methods of peptide synthesis, analysis of peptides and proteins, primary, secondary and tertiary structure. Nomenclature of heterocyclic compounds. Structures and properties of aromatic and non-aromatic heterocyclic compounds. Compounds containing nitrogen, oxygen and sulfur as heteroatoms of various ring sizes. Selected methods of synthesis of heterocyclic compounds.

Laboratory:
1. Isolation of caffeine from tea leaves and analysis by thin layer chromatography.
2. Synthesis of 1,2,3,4,6-penta-O-acetyl-α-D-glucopyranose and 1,2,3,4,6-penta-O-acetyl-β-D-glucopyranose.
3. Separation of essential oils by column chromatography:
- isolation of (S)-(+)-carvone and (R)-(+)-limonene from caraway oil,
- isolation of eugenol and (-)-β-caryophyllene from clove oil.
4. Synthesis of isoborneol from camphor.
5. Synthesis of 3,5-diphenylisoxazoline.

Total student workload

Hours with teachers: - participation in lectures – 15 h - participation in laboratories – 45 h - consultations – 31 h Time devoted to individual student work: - preparation for the lab, preparation of lab reports – 20 h - preparation for tests – 20 h - preparation for the exam – 44 h

Learning outcomes - knowledge

W1: has in-depth knowledge of chemistry, which constitutes the theoretical basis for education in the field of medical chemistry; knows the main development trends regarding the use of chemical methods in medicine and pharmacy – K_W01 W2: knows and understands the positive aspects and disadvantages related to the synthesis and technology of active compounds, including copyright protection – K W02 W3: knows and understands in-depth the analytical methods, instrumental measurement techniques used in medicine and pharmacy and their importance for the progress of exact and natural sciences, knowledge of the world and the development of humanity – K W03

Learning outcomes - skills

U1: is able to use knowledge of chemistry in medicine and pharmacy, properly select analytical and instrumental methods used in medicine – K_U01 U2: is able to independently and in a team plan, implement and expand knowledge of chemical methods used in medical research and solve problems based on the issues learned in the field of medical chemistry – K_U03 U3: is able to use the acquired knowledge in the field of medical chemistry in related fields and scientific disciplines – K_U05

Learning outcomes - social competencies

K1: is able to formulate and present opinions on chemical issues in medicine and pharmacy and is aware of the importance of acquired knowledge in scientific and professional work – K_K01 K2: understands ethical and social aspects of practical use of acquired knowledge and skills – K_K02 K3: is able to share his/her knowledge and justify the importance of the development of chemical sciences in the medical aspect – K_K03

Teaching methods

Lecture: Conventional lecture with the use of multimedia presentations. Laboratory: Synthesis of preparations and analysis of obtained compounds, completed with the preparation of research reports.

Observation/demonstration teaching methods

- display

Expository teaching methods

- informative (conventional) lecture

Exploratory teaching methods

- laboratory

Type of course

compulsory course

Prerequisites

Basic knowledge of general, analytical and organic chemistry at first-cycle level.

Course coordinators

Agnieszka Tafelska-Kaczmarek

Assessment criteria

Assessment methods
Lecture: K_W01, K_W02, K_W03
Laboratory: K_W02, K_W03, K_U01, K_U03
Assessment criteria:
Lecture: written exam; final grade is the sum of points obtained from the exam (80%) and laboratory (20%);
Required threshold for a satisfactory grade – 50%, satisfactory plus – 61%, good – 66%, good plus – 76%, very good – 81%.
Laboratory: crediting based on the results obtained from tests (50%) and descriptions of prepared preparations (50%), continuous assessment of the student during classes
Required threshold for a satisfactory grade – 50%, satisfactory plus – 61%, good – 66%, good plus – 76%, very good – 81%.

Practical placement

Not applicable

Bibliography

1. A. Kołodziejczyk, Związki naturalne, Wyd. 2, PWN 2004.
2. J. McMurry, Chemia Organiczna T. 4 i 5, Wyd. 3, PWN, Warszawa, 2007/2010.
3. J. Młochowski, Chemia związków heterocyklicznych, Wydawnictwo Naukowe PWN, Warszawa 1994.
4. J. A. Joule, G. F. Smith, Chemia związków heterocyklicznych, PWN, Warszawa 1984.
5. T. Eichert, S. Hauptmann, A. Speicher, The chemistry of heterocycles, Wiley-VCH, Weinheim 2010.

Additional information

Additional information (registration calendar, class conductors, localization and schedules of classes), might be available in the USOSweb system:

Description of 0600-S2-CM-CBO in USOSweb