Elements of the pharmaceutical chemistry
0600-S1-CM-ECF
Lectures:
Lectures will cover elements of pharmaceutical chemistry.
Lecture topics will include at least
1. the origins of medicinal and pharmaceutical chemistry.
2. the concept of biological and pharmacological activity of substances, linking structure to activity.
3. Molecular mechanisms of drug action, receptors, changes in receptor reactivity; carriers of molecules, enzymes.
4 Drug metabolism
5. prodrugs and transport systems
6. methods of drug discovery: with and without lead structures.
Total student workload
1. 20 hours lecture, i.e. 20 contact hours,
2. 5 hours consultations, i.e. 5 contact hours,
3. the total student workload is 25 hours.
Learning outcomes - knowledge
W1: has knowledge of the structure, properties, metabolism and structural design of active compounds, K_W06
W2: has theoretical and practical knowledge of the methods of modern synthesis of biologically active compounds and their identification, K_W05
W3: knows and understands the chemical and biochemical mechanisms of action of chemical compounds used as active substances, K_W06, K_W08
W4: knows the chemical compounds used as active substances, including international nomenclature and synonyms, K_W06
Learning outcomes - skills
U1: Can use an extended knowledge of the basic branches of chemistry and apply it creatively in the field of pharmaceutical chemistry, K_U01, K_U03
U2: Can explain the properties of an active substance based on its structure and mechanism of action, assign it to a relevant group and list the possibilities for its modification, K_U03, K_U07
U3: can evaluate the influence of physico-chemical and chemical properties of compounds on their metabolism and toxicity, K_U03, K_U07
U4: is able to describe in technical terms the functions of active substances and their metabolism, K_U08
Learning outcomes - social competencies
K1: Understand the practical applicability and economic relevance of chemical compounds and new materials and the potential risks associated with their use; identify and resolve dilemmas. K_K01, K_K02, K_K03
Expository teaching methods
- informative (conventional) lecture
- problem-based lecture
- participatory lecture
Type of course
compulsory course
Prerequisites
General knowledge of chemistry and biology not beyond secondary school level.
Course coordinators
Assessment criteria
Evaluation criteria:
Lecture: credit by oral or written examination (form to be agreed with students).
Pass threshold: 50%, pass plus: 61%, good: 66%, good plus: 76%, very good: 81%.
Additional information
Additional information (registration calendar, class conductors,
localization and schedules of classes), might be available in the USOSweb system: