Drug Chemistry 0600-S1-CM-CL

Lectures:
The aim of the lecture is to familiarise students with the basic knowledge of the chemical structure, physico-chemical and biological properties of drugs from different groups, the chemical transformations they undergo in the body (metabolism), the mechanisms of action of drugs from a chemical point of view, the relationship between chemical structure and pharmacological action and the therapeutic value of drugs.
Laboratories:
In the laboratories, students are introduced to methods of qualitative analysis of active substances (organic, inorganic); how to determine the identity of an active substance based on pharmacopoeial procedures. Laboratory credits will be awarded on the basis of self-conducted analyses consisting of the identification of an active substance individually and in a binary mixture in accordance with the analytical methods and procedures learnt in the FP. The active substances and excipients analysed are at least acetylsalicylic acid, citric acid, benzoic acid, sodium benzoate, calcium lactate, paracetamol, cholesterol, ampicillin, ascorbic acid, lidocaine hydrochloride, metronidazole, chlorchinaldol.

Total student workload

1. 105 contact hours Lecture 15h Laboratory 60h Consultation 30h 2. 25 h Individual work 3. 20 hrs Preparation time for the assessment process Total workload 150 h

Learning outcomes - knowledge

W1: Has knowledge of the structure, properties, metabolism and structural design of active compounds, K_W06 W2: knows the nomenclature and classification of drugs in the pharmacological-therapeutic-chemical system and the mechanism of action and biotransformation of drugs in their various forms K_W05, K_W06 W3: knows the basic pharmacological classification of drugs, the chemical and biochemical mechanisms of drug action and can explain the dependence of drug action, persistence and absorption on chemical structure, K_W05, K_W06

Learning outcomes - skills

U1: knows and understands test methods for qualitative and quantitative evaluation and is therefore able to carry out quality control of medicinal products and to propose an appropriate analytical method, including validation, for a specific purpose, K_U03, K_U07 U2: is able to assess the influence of physico-chemical and chemical properties of compounds on their metabolism and toxicity, K_U03, K_U07 U3: is able to describe in a technical language the functions of active substances and their metabolism, K_U08

Learning outcomes - social competencies

K1: Understand the practical applicability and economic relevance of chemical compounds with biological activity and new materials, and the potential risks associated with their use; identify and resolve related dilemmas. K_K01, K_K02, K_K03

Expository teaching methods

- participatory lecture
- informative (conventional) lecture
- problem-based lecture

Exploratory teaching methods

- observation
- laboratory
- experimental

Prerequisites

Knowledge of basic chemistry (qualitative analysis of cations and anions) and organic chemistry

Course coordinators

Marta Ziegler-Borowska

Assessment criteria

Lecture: W1-W3, U1
Laboratory: W2, U1-U3
Evaluation criteria:
Lecture: credit by oral or written examination (form to be agreed with students).
Required pass: 50%, pass plus: 61%, good: 66%, good plus: 76%, very good: 81%.
Laboratory:
Practical credit on the basis of completed tasks, an input test and a final colloquium.

Bibliography

1. Gringuaz A.: Introduction to Medical Chemistry, A.Wiley – vch, 1997.
2. Wolff M.E. (red.): Burger’s Medcal Chemistry and Drug discovery, A.Wiley – Interscience Publication 1995.

Additional information

Additional information (registration calendar, class conductors, localization and schedules of classes), might be available in the USOSweb system:

Description of 0600-S1-CM-CL in USOSweb