Bioinorganic Chemistry 0600-S1-CM-CBioN

This interdisciplinary lecture discusses: - the action of elements important for life, - the function in a living organism of organic molecules (so-called life molecules) interacting as bioligands with metal ions (biometals), especially from the point of view of coordination chemistry, - the use of coordination compounds in medicine. T
Topics covered:
1. Bioelements and toxic metals.
2. Metals in biological processes.
3. Relations between the chemical properties of a metal ion and its biological function.
4. The role of organic molecules (so-called life molecules) in a living organism interacting as bioligands with metal ions (biometals).
5. Metalloenzymes and metal ion-activated enzymes.
6. Oxygen transporters and oxygen-transporting proteins.
7. Properties of reactive oxygen species and their biological effects.
8. Metals in medicine; Inorganic chemotherapeutics as an introduction to drug chemistry.

Laboratory
During laboratory classes, students perform three exercises:
1. Application of IR spectroscopy for determining cytotoxic structures
complexes of metals in the solid state.
2. Lipophilicity test of coordination compounds selected
using UV-VIS spectroscopy.
3. Study of the reactivity of coordination compounds to glutathione.

Term 2023/24L:

None

Total student workload

lecture, (15h), laboratory (15h), i.e. 30 contact hours, the total time of the student's workload is 30h = 1 ECTS

Learning outcomes - knowledge

Student: K_W01: knows bioinorganic chemistry and uses the appropriate terminology and nomenclature X1A_W01 K_W08: defines the concepts and explains the mechanisms of oxidative and carcinogenic processes in the human body P1A_W01; P1A_W03; P1A_W04; P1A_W05; P1A_W08 K_W11: knows to understand the basic problems related to, among others, the transport of oxygen X1A_W02; X1A_W03 X1A_W04; X1A_W05 P1A_W10; P1A_W11

Learning outcomes - skills

Student K_U01: can analyze and solve problems of bioinorganic chemistry based on the acquired knowledge X1A_U01; X1A_U06 X1A_U07 P1A_U01; P1A_U06 P1A_U07; P1A_U09 K_U07: can determine the structure and function of proteins, DNA, metalloenzymes, X1A_U01; X1A_U06; X1A_U07 K_U08: can describe and present chemical and biological issues using specialist language X1A_U05; X1A_U0; X1A_U08 P1A_U08; P1A_U09 P1A_U10 K_U09: can independently expand knowledge in the field of bioinorganic chemistry using scientific literature X1A_U07: P1A_U02 P1A_U03; P1A_U05 P1A_U10.

Learning outcomes - social competencies

Student K_K01: understands the need for continuous improvement and improvement of competencies in the field of bioinorganic chemistry X1A_K01; X1A_K05 P1A_K01; P1A_K05 P1A_K07 K_K03: can plan and deliver a presentation based on the available scientific literature X1A_K03.P1A_K04 K_K04: identifies and solves problems related to bioinorganic chemistry X1A_K04, P1A_K03; P1A_K04 P1A_K05 K_K06: understands the ethical and social aspects of using acquired knowledge and skills X1A_K07 P1A_K01; P1A_K07.

Teaching methods

(in Polish) Wykład Metody dydaktyczne eksponujące - pokaz Metody dydaktyczne podające - wykład informacyjny (konwencjonalny), wykład konwersatoryjny laboratoryjna Metody dydaktyczne poszukujące - ćwiczeniowa, seminaryjna.

Observation/demonstration teaching methods

- display

Expository teaching methods

- informative (conventional) lecture
- problem-based lecture

Exploratory teaching methods

- laboratory

Prerequisites

Basic knowledge of biochemistry and coordination chemistry.

Course coordinators

Iwona Łakomska

Assessment criteria

Lecture
written exam – K_W01, K_W03; K_W08; K_W11; K_U01; K_U03; K_U07; K_U08; K_U09; K_K01; K_K03; K_K06.
Laboratory - preparation of reports on laboratory tasks performed – K_W01, K_W03; K_W08; K_W11; K_U01; K_U03; K_U07; K_U08; K_U09; K_K01; K_K03; K_K06

Practical placement

Not applicable

Bibliography

1. R. Hay, Chemia bionieorganiczna, PWN 1990.
2. S. Lippard, J.M. Berg, Podstawy chemii bionieorganicznej, PWN 1998.
3. I. Bertini, H. B. Gray, S. J. Lippard, J.S. Valentine, Bioinorganic chemistry, University Science Books
4. G. Bartosz, Druga twarz tlenu, PWN 2003.
5. H. Koroniak, J. Barciszewski, Na pograniczu chemii i biologii, Wydawnictwo Naukowe UAM, Poznań 2000.
6. L. Stryer, Biochemia, PWN 2007.
7. J.M. Perez, M.A. Fuertes, C. Alonso, Metal Compound in Cancer Chemotherapy, Research Singpost, India 2005.
8. B. Lippert, Cisplatin. Chemistry and Biochemistry of a Leading Anticancer Drug, Wiley-VCH, Weinheim 1999.
9. G. M. Blackburn, M. J.Gait, D. Loakes, D.M. Williams, Nucleic Acids in Chemistry and Biology, RSC2006.
10. H-B. Kraatz, N. Metzler-Nolte, Concepts and models in Bioinorganic Chemistry, Wiley 2006.

Term 2023/24L:

None

Additional information

Additional information (registration calendar, class conductors, localization and schedules of classes), might be available in the USOSweb system:

Description of 0600-S1-CM-CBioN in USOSweb