Crystal engineering in the pharmaceutical industry 0600-OG-EN-CEPI

The lectures will cover such areas as:
1. Molecular/crystal structures and their visualisation
2. Intermolecular interactions
3. Crystal engineering
4. Polymorphism and problems connected with its appearance in the pharmaceutical industry
5. Methods to characterize polymorphs
6. Crystal lattice energies and crystal structures prediction methods
6. Multi-component crystals
7. Patent matters

Total student workload

Contact hours with teacher: - participation in lectures 30 hrs - consultation with lecturer 10 hrs Self-study hours: - reading literature - 10 hrs - preparation for examination - 25 hrs Altogether: 75 hrs (3 ECTS)

Learning outcomes - knowledge

W1: has basic knowledge of issues faced in the pharmaceutical industry connected with the solid-state W2: knows about polymorphs and their impact on pharmaceutical development W3: is familiar with basic concepts of crystal engineering, e.g. intermolecular interactions W4: is acquainted with a range of crystalline materials and their methods of characterization W5: has basic knowledge on the significance of structural properties from a patent perspective

Learning outcomes - skills

U1: is able to list issues in the pharmaceutical industry related to the solid-state U2: is capable of identifying different polymorphic forms U3: has basic skills in indicating different types of crystalline materials U4: can explain the importance of solid-state properties on the protection of Intellectual Property

Learning outcomes - social competencies

K1: understands the significance of multi-disciplinary collaboration within the pharmaceutical industry K2: understands the need for basic research to support pharmaceutical development K3: recognizes the importance of the interplay between research and Intellectual Property

Teaching methods

informative lecture

Expository teaching methods

- informative (conventional) lecture

Prerequisites

none

Course coordinators

Liliana Dobrzańska

Assessment criteria

- Written exam 1-2 hours.
Criteria:
Fail (< 50%)
Satisfactory (50-60%) – the student has basic understanding of the formation of different types of crystalline solids
Satisfactory plus for the grade (61-65%) – the student has basic understanding of the formation of different types of crystalline solids and knowledge of various intermolecular interactions
Good (66-75%) – the student has basic understanding of the formation of different types of crystalline solids and knowledge of various intermolecular interactions. He/she understands the concept of polymorphism and its significance within the pharmaceutical industry.
Good plus (76-80%) – the student has basic understanding of the formation and characterization of different types of crystalline solids and knowledge of various intermolecular interactions. He/she understands the concept of polymorphism and its significance within the pharmaceutical industry. The student has knowledge on the importance of solid-state properties in relationship to Intellectual Property.
Very good (> 80%)
Has in-depth knowledge of all aspects of the subject matter.

Practical placement

not applicable

Additional information

Additional information (registration calendar, class conductors, localization and schedules of classes), might be available in the USOSweb system:

Description of 0600-OG-EN-CEPI in USOSweb